Methiopropamine Powder

Methiopropamine Powder

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Description

Buy Methiopropamine Powder online Europe

Product Description.Buy Methiopropamine Powder online Europe

Methiopropamine (also known as MPA, Methedrene, Syndrax) is a thiophene ring-based structural analog of methamphetamine. Mild euphoria and increased levels of awareness are said to be some of the effects that Methiopropamine can have. It is approximately one third as potent as dextroamphetamine.Buy Methiopropamine Powder online Europe;Methiopropamine (MPA) is a thiophene ring-based structural analog of methamphetamine originally reported in 1942.[1] Chemically it is not a phenethylamine or amphetamine and is not their functional analog either. It originally appeared for public sale in the UK in December 2010 as a “research chemical” or “legal high”, recently branded as Blow.[2] It has limited popularity as a recreational stimulant

Pharmacology

Methiopropamine functions as a selective norepinephrine-dopamine reuptake inhibitor that is approximately 1.85 times more selective for norepinephrine than dopamine. It is approximately one third as potent as dextroamphetamine as a norepinephrine reuptake inhibitor and one fifth as much as a dopamine reuptake inhibitor. It displays negligible activity as a serotonin reuptake inhibitor.

Methiopropamine has the potential for significant acute toxicity with cardiovascular, gastrointestinal, and psychotic symptoms.

Metabolisms

Methiopropamine metabolism is somewhat similar to methamphetamineHydroxylationdemethylation and deamination are in common. Formation of thiophene S-oxide is different, as is the end product which will probably be (substitutedthiophene-2-carboxylic acid. It is then excreted in urine. Compounds on red are inactive.

For N-alkyl amphetamines, deamination and Ndealkylation are the major elimination pathways and renal excretion is a minor one.[7] Methiopropamine is metabolized into active thiopropamine, 4-hydroxymethiopropamine and thiophene Soxides.[8][9] These Ndemethylated metabolites are further deaminated by the cytochrome P450 enzyme CYP2C19 in the liver transforming them into inactive 1-(thiophen-2-yl)-2-propan-2-one which can be seen as a phenylacetone derivative.[10][11]

Thiophene-2-carboxylic acid is the final major metabolic product. It is very hydrophilic and is excreted in urine. Methiopropamine and especially thiopropamine are also excreted renally, unchanged.

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Cas No: 801156-47-8
Formula: C8H13NS
IUPAC: 1-(Thiophen-2-yl)-2-methylaminopropane
Appearance:
Purity:

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