Furanylfentanyl powder

Furanylfentanyl powder

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Description

Buy Furanylfentanyl powder online Europe

Product Description.

Furanylfentanyl (Fu-F) is an opioid analgesic that is an analog of fentanyl. The ED value of this chemical is 0.02mg/kg in mice. This makes it approximately one fifth as potent as fentanyl.Buy Furanylfentanyl powder online Europe

Product Name: Furanylfentanyl Powder
Cas No: 101345-66-8
Formula: C24H26N2O2
IUPAC: N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylfuran-2-carboxamide
Appearance: White powder
Purity: above 98.5%

Route of administration and dosage
Furanylfentanyl can be administered orally as a powder
(including in capsules), as tablets, or as a solution (using
nasal sprays) or by insufflation of a powder; it can also
be administered intranasally or sublingually via a spray;
inhaled by smoking or vaporising; and, administered
transdermally by injection (intravenous and
intramuscular). Furanylfentanyl has also been offered for
sale in the form of propylene glycol/glycerol solutions
(e.g. 30 mg/mL), presumably intended for vaporisation
as an e-liquid in electronic cigarettes (‘vaping’).Buy Furanylfentanyl powder online Europe

Pharmacology
Pharmacodynamics
Currently available data on the pharmacology of
furanylfentanyl are limited to studies investigating its
binding and functional activity at opioid receptors in
vitro, and its antinociceptive properties in mice. Briefly,
these data show that furanylfentanyl is a µ-opioid
receptor agonist with antinociceptive properties similar
to fentanyl.
Data from in vitro binding studies suggest that
furanylfentanyl binds to the µ-opioid receptor (MOR)
with high selectivity over the κ- (KOR) and δ-opioid
receptors (DOR). Furanylfentanyl shows higher binding
affinity than morphine (at MOR and DOR) and fentanyl
(at MOR, KOR and DOR). Data from in vitro functional
studies suggest, however, that furanylfentanyl functions
as an agonist with lower functional efficacy when
compared to morphine and fentanyl.
Data from studies in mice examining the antinocic

Pharmacokinetics
Studies on the pharmacokinetics of furanylfentanyl are
limited to the identification of metabolites. Due to its
lipophilicity, furanylfentanyl, like fentanyl, is expected to
readily cross the blood-brain barrier and also diffuse into
fat and other tissues and is thus likely to have a large
volume of distribution.
The pharmacokinetics and the metabolic pathway of
furanylfentanyl are expected to share some similarities
with other fentanils. As such, furanylfentanyl could be
predicted to undergo metabolism by hepatic CYP450
isoenzymes, including CYP2C19, CYP2D6, CYP3A4, and
CYP3A5.
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