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Methadone is a synthetic opioid medication or drug, which is commonly prescribed as a treatment and harm reduction approach for opioid use disorder, in particular, to help people overcome heroin addiction. A powerful painkiller, methadone is also sometimes prescribed to treat severe pain. The main therapeutic effects of methadone are to reduce heroin withdrawal symptoms, prevent heroin and other opiates from producing euphoria and reduce pain perception.Buy Methadone Powder Online Europe
Methadone can appear as a tablet, powder, or liquid, and is typically administered as a measured oral dose in the form of a green syrup, or in a sweet orange or cherry flavored drink. Methadose, a relatively new methadone formula, is ten times stronger than methadone, requiring a much smaller dose to be given.Buy Methadone Powder Online Europe.BUY DMT POWDER ONLINE EUROPE
Methadone Powder – Clinical Pharmacology
Mechanism of Action.
Methadone hydrochloride is a mu-agonist; a synthetic opioid analgesic with multiple actions quantitatively similar to those of morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. The principal actions of therapeutic value are analgesia and detoxification or maintenance in opioid addiction. The methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe.
Some data also indicate that methadone acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. The contribution of NMDA receptor antagonism to methadone’s efficacy is unknown.
When administered orally, methadone is approximately one-half as potent as when given parenterally. Oral administration results in a delay of the onset, a lowering of the peak, and an increase in the duration of analgesic effect.
Effects on the Central Nervous System
Methadone produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical stimulation.
Methadone causes miosis, even in total darkness. Pinpoint pupils are a sign of opioid overdose but are not pathognomonic (e.g., pontine lesions of hemorrhagic or ischemic origins may produce similar findings). Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations.
Some NMDA receptor antagonists have been shown to produce neurotoxic effects in animals.
Product Name: Methadone Powder
Cas No: 76-99-3
Appearance: White powder
Purity: above 98.5%