Sibutramine Powder

Sibutramine Powder

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Product Description

Sibutramine is an appetite suppressant. It was widely marketed and prescribed as an adjunct in the treatment of obesity along with diet and exercise. Sibutramine has been used to produce appetite suppression for the purpose of attaining weight loss in the treatment of patients with obesity.Buy Sibutramine Powder online Europe

Sibutramine is a serotonin and norepinephrine reuptake inhibitor which has been used for short- and long-term therapy of obesity.

Sibutramine Hydrochloride is the hydrochloride salt form of sibutramine. (sibutramine hydrochloride monohydrate) is an orally administered agent for the treatment of obesity. Chemically, the
active ingredient is a racemic mixture of the (+) and (-) enantiomers of cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-α­
(2-methylpropyl)-, hydrochloride, monohydrate, and has an empirical formula of C17H29Cl2NO. Its molecular weight is 334.33.Buy Sibutramine Powder online Europe

Sibutramine hydrochloride monohydrate is a white to cream crystalline powder with a solubility of 2.9 mg/mL in pH 5.2 water. Its
octanol: water partition coefficient is 30.9 at pH 5.0.
Each MERIDIA capsule contains 5 mg, 10 mg, and 15 mg of sibutramine hydrochloride monohydrate. It also contains as inactive
ingredients: lactose monohydrate, NF; microcrystalline cellulose, NF; colloidal silicon dioxide, NF; and magnesium stearate, NF in a
hard-gelatin capsule [which contains titanium dioxide, USP; gelatin; FD&C Blue No. 2 (5- and 10-mg capsules only); D&C Yellow
No. 10 (5- and 15-mg capsules only), and other inactive ingredients].BUY LSD BLOTTERS EUROPE
CLINICAL PHARMACOLOGY
Mode of Action
Sibutramine produces its therapeutic effects by norepinephrine, serotonin and dopamine reuptake inhibition. Sibutramine and its major
pharmacologically active metabolites (M1 and M2) do not act via release of monoamines.
Pharmacodynamics
Sibutramine exerts its pharmacological actions predominantly via its secondary (M1) and primary (M2) amine metabolites. The parent
compound, sibutramine, is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine reuptake in vivo, but not

in vitro. However, metabolites M1 and M2 inhibit the reuptake of these neurotransmitters both in vitro and in vivo.

In human brain tissue, M1 and M2 also inhibit dopamine reuptake in vitro, but with ~3-fold lower potency than for the reuptake

inhibition of serotonin or norepinephrine.

Product Name: Sibutramine
Cas No: 106650-56-0
Formula: C17H26ClN
Appearance: White powder
Purity: above 98.5%

Additional information

Quantity

25 Grams, 50 Grams, 100 Grams, 250 Grams, 500 Grams

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